A Receptor in the Brain Makes Cocaine Relapse More Likely

Posted on 10/03/2010 by meg

“Drugs are addictive because they "hijack" the brain's reward system, which is actually intended to make it pleasurable to eat and have sex, behaviors that are necessary for survival and reproduction.”

Cocaine, a highly addictive drug, also technically known as benzoylmethylecgonine, is a crystalline tropane alkaloid (naturally occurring chemical compound containing nitrogen) that is obtained from the leaves of the coca plant.

The drug acts as a stimulant of the central nervous system, an appetite suppressant, and a topical anesthetic. Specifically, cocaine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), which mediates functionality of said neurotransmitters.

Basically, cocaine acts as a chemical in the brain that blocks the action of transporters of serotonin, norepinephrine and dopamine. This blocking increases extracellular concentrations around those specific neurotransmitters and increases their affects. In this type environment, higher levels of serotonin, noradrenalin, adrenaline or dopamine can be transmitted leading to increased euphoria.

Cocaine is highly addictive because of the way it affects the mesolimbic reward pathway (a pathway for dopamine). The addiction can persist long after periods of sobriety. The effect cocaine has on the brain is long-lasting making relapse very likely. For instance, relapse may occur simply by exposure to a situation associated with its use.

New research from Linköping University has pinpointed a specific molecule in the brain that may affect the addict’s chance of relapse. According to the study, led by David Engblom, associate professor of neurobiology at Linköping University in Sweden, “a receptor for the signal substance glutamate (mGluR5), in a part of the brain called the striatum, plays a major role in relapses.”

Also, he continues,
"our findings show that the mice who lacked the receptor were less prone to relapse. This is due the fact that their reaction to reward had not been etched into their memories in the same ways as in normal mice. The receptor seems to be a prerequisite for objects or environments that were previously associated with taking drugs, or something else rewarding, to create a craving".
This discovery should lead to further research into the understanding of cocaine addiction and its effects on the brain, as well as, the development of new methods for treating cocaine addiction.

Why the Craving for Cocaine Won’t Go Away
Cocaine
Serotonin–norepinephrine–dopamine reuptake inhibitor

© www.understandingaddictions.com

No Response to "A Receptor in the Brain Makes Cocaine Relapse More Likely"

Leave A Reply

Labels

(+)-naloxone 6-acetylmorphine (6AM) Addiction Adenovirus Adolescence Adrenaline Aftershave Airplaning Alcohol Alcohol Poisoning Alcoholic Alcoholism Amphetamine Anaplasticity Anterior Cingulate Cortex Antibodies Anxiety Appetite Assault Attention Bath Salts Battery Acid Beer Belfast Benefits Benzoylmethylecgonine Bergen Facebook Addiction Scale Binge Drinking Biochemical Biological Clock Body Language Bone Fracture Bones Bonsai Grow Boot Camp Brain Brain Damage Break-Up British Columbia Bum Rushing Buprenorphine California Dreaming Canada Cancer Casino Cathinones Centers for Disease Control and Prevention China Choking Game Cigarette Circadian Rhythm Cirrhosis Citric Acid Cloud Nine Cocaine Cocaine Vaccine Cognitive Behavioral Therapy Common Cold Compulsivity Constitutional Right Content-Control Software Counselor Crack Craving Cues Death Decision-Making Demerol Dentist Dependence Dependency Depression Dilaudid Dopamine Dr. Drew Drain Cleaner Drug E-Cigarette Electric Shock Electronic Cigarette Emotion Employment Programs Engrams Exceptional Access Program (EAP) Facebook Facebook Addiction Failure Fainting Game Family Finances Flat Liner fMRI France Funky Chicken Gamblers Anonymous Gambling Genes Glutamate Government Grey Matter Hapten Harm Reduction Harvey Wallbanger Health Health Care Heart Attack Heart Disease Heroin Hillbilly Heroin HIV/AIDS Homelessness Hospitalization Human Rights Hunger Hurricane Charlie Hydrocodone Hydromorphone Hygiene Hypothalamus Illicit Drug Use Immune System Immune-Addiction Response Immunopharmacotherapy Implant Impulse Control Disorders Injection Injuries Instinct Internet Addiction Internet Gambling Intervention Ivory Wave Jay Leno Knockout Game Lantern Fuel Liver Long Term Depression Love Ludomania MADD Medial Prefrontal Cortex Medication Memories Memory Memory Traces Meperidine Mephedrone Mesolimbic Reward Pathway Methadone Methamphetamine Methylenedioxypyrovalerone (MDPV) Methylone Mid-Brain Money Montreal Morphine Motivation Mouthwash mRNA Muscle Control Naloxone Naltrexone Narcotic Negative Consequences Neural Pathway Nicotine Nicotine Gum Nicotine Patch Noradrenalin Norepinephrine Obsessive-Compulsive Online Gambling Ontario Disability Support Program (ODSP) Ontario Drug Benefit (ODB) Ontario Works (OW) Opiate Opioid Oral Hygiene Orbitofrontal Cortex Osteoporosis Ottawa Overdose Oxycodone Oxycontin Oxyneo Pain Pain Management Painkiller Paint Thinner Pass-out Game Pathological Computer Use Pathological Gambling Percocet Placebo Poker Pop Pre-frontal Cortex Prefrontal Cortex Prescription Drugs Propoxyphene Psychoactive Purple Dragon Rats Recovery Red Dove Rehab Rejection Relapse Relationships Research Research Validity Reward Reward and Punishment Risky Sexual Behavior RNA Safe Injection Site Salt Scarface Sensory Perception Serotonin Sex Addiction Shame Sleep/Wake Cycle Sleeper Hold Slot Machines Smoking Smoking-Cessation SNDRI Sobriety Social Assistance Social Media Social Security Soda Soda Addiction Sodium Sodium Ion Channel Space Monkey Speech Star Dust Striatum Subutex Successful Treatment Supreme Court of Canada Synapse Teenagers Tobacco Toll-Like receptor 4 (TLR4) Tooth Decay Tooth Enamel Tooth Erosion Treatment Trillium Drug Program Urine Sample Vaccine Vancouver Vanilla Sky Vaporize Vicodin Virus Vivitrol Welfare Wet Program White Lightning White Matter Wine Withdrawal

Health Blogs - Blog Rankings rdirectory.net