Posted on 7/22/2011 by meg
According to researchers at The Scripps Research Institute, an “immunopharmacotherapy” type of treatment for heroin could be on the horizon. Their proven research with animal models confirms that they have developed a vaccine that counteracts the heroin high.
Additionally, the antibodies produced by this new vaccine are also capable of preventing other psychoactive compounds that are metabolized from heroin from reaching the brain and producing euphoric effects.
“‘In my 25 years of making drug-of-abuse vaccines, I haven't seen such a strong immune response as I have with what we term a dynamic anti-heroin vaccine,’ said the study's principal investigator, Kim D. Janda, the Ely R. Callaway, Jr. Chair in Chemistry and a member of The Skaggs Institute for Chemical Biology at Scripps Research. ‘It is just extremely effective. The hope is that such a protective vaccine will be an effective therapeutic option for those trying to break their addiction to heroin.’”Regrettably, authors of this study claim that heroin abuse and addiction are not only incredibly destructive to the addict, but to the world as a whole, as the cost of this disease is estimated at $22 billion in productivity loss, criminal activity, medical care, and social welfare, in the United States alone. Not to mention the high rates of HIV transmission due to needle sharing.
As a result, many other researchers have attempted to create such a vaccine without success partially because heroin is an elusive target that metabolizes into multiple substances that all generate psychoactive effects. Because of this, researchers in this study developed a vaccine that targets a chemical called 6-acetylmorphine (6AM) and morphine in addition to heroin. And, like heroin, 6-acetylmorphine (6AM) easily crosses the blood-brain barrier to latch onto opioid receptors in the brain. Essentially, the vaccine produces antibodies that neutralize a constantly changing target.
“The researchers linked a heroin-like hapten (a small molecule that elicits an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with Alum, an adjuvant (vaccine additive), to create a vaccine "cocktail." This mixture slowly degraded in the body, exposing the immune system to different psychoactive metabolites of heroin such as 6AM and morphine.”Researchers observed differences in rats injected with a vaccine that acted on morphine alone in comparison to the dynamic vaccine, which acted on several chemical compounds. Results showed that the dynamic heroin vaccine created an immune response that generated strong polyclonal antibodies against heroin.
“In addition, the study found that addicted rats were less likely to "self-administer" heroin by pressing on a lever after several booster shots of the vaccine. Only three of the seven rats that received the heroin vaccine self-administered heroin. In contrast, all of the control rats, including those given the morphine vaccine, self-administered the drug.”Fortunately, the heroin vaccine is highly specific as it only produces antibodies in response to the heroin and 6AM, therefore it will not interfere if used in combination with other treatments, such as methadone, naltrexone, and naloxone.
Scientists Create Vaccine Against Heroin High
“The Scripps Research team has recently begun an exciting collaboration with researchers at the Walter Reed Army Institute of Research to see if it is feasible to develop a dual-purpose vaccine against HIV and for the treatment of heroin addiction in a single shot, Janda said.”
(+)-naloxone 6-acetylmorphine (6AM) Addiction Adenovirus Adolescence Adrenaline Aftershave Airplaning Alcohol Alcohol Poisoning Alcoholic Alcoholism Amphetamine Anaplasticity Anterior Cingulate Cortex Antibodies Anxiety Appetite Assault Attention Bath Salts Battery Acid Beer Belfast Benefits Benzoylmethylecgonine Bergen Facebook Addiction Scale Binge Drinking Biochemical Biological Clock Body Language Bone Fracture Bones Bonsai Grow Boot Camp Brain Brain Damage Break-Up British Columbia Bum Rushing Buprenorphine California Dreaming Canada Cancer Casino Cathinones Centers for Disease Control and Prevention China Choking Game Cigarette Circadian Rhythm Cirrhosis Citric Acid Cloud Nine Cocaine Cocaine Vaccine Cognitive Behavioral Therapy Common Cold Compulsivity Constitutional Right Content-Control Software Counselor Crack Craving Cues Death Decision-Making Demerol Dentist Dependence Dependency Depression Dilaudid Dopamine Dr. Drew Drain Cleaner Drug E-Cigarette Electric Shock Electronic Cigarette Emotion Employment Programs Engrams Exceptional Access Program (EAP) Facebook Facebook Addiction Failure Fainting Game Family Finances Flat Liner fMRI France Funky Chicken Gamblers Anonymous Gambling Genes Glutamate Government Grey Matter Hapten Harm Reduction Harvey Wallbanger Health Health Care Heart Attack Heart Disease Heroin Hillbilly Heroin HIV/AIDS Homelessness Hospitalization Human Rights Hunger Hurricane Charlie Hydrocodone Hydromorphone Hygiene Hypothalamus Illicit Drug Use Immune System Immune-Addiction Response Immunopharmacotherapy Implant Impulse Control Disorders Injection Injuries Instinct Internet Addiction Internet Gambling Intervention Ivory Wave Jay Leno Knockout Game Lantern Fuel Liver Long Term Depression Love Ludomania MADD Medial Prefrontal Cortex Medication Memories Memory Memory Traces Meperidine Mephedrone Mesolimbic Reward Pathway Methadone Methamphetamine Methylenedioxypyrovalerone (MDPV) Methylone Mid-Brain Money Montreal Morphine Motivation Mouthwash mRNA Muscle Control Naloxone Naltrexone Narcotic Negative Consequences Neural Pathway Nicotine Nicotine Gum Nicotine Patch Noradrenalin Norepinephrine Obsessive-Compulsive Online Gambling Ontario Disability Support Program (ODSP) Ontario Drug Benefit (ODB) Ontario Works (OW) Opiate Opioid Oral Hygiene Orbitofrontal Cortex Osteoporosis Ottawa Overdose Oxycodone Oxycontin Oxyneo Pain Pain Management Painkiller Paint Thinner Pass-out Game Pathological Computer Use Pathological Gambling Percocet Placebo Poker Pop Pre-frontal Cortex Prefrontal Cortex Prescription Drugs Propoxyphene Psychoactive Purple Dragon Rats Recovery Red Dove Rehab Rejection Relapse Relationships Research Research Validity Reward Reward and Punishment Risky Sexual Behavior RNA Safe Injection Site Salt Scarface Sensory Perception Serotonin Sex Addiction Shame Sleep/Wake Cycle Sleeper Hold Slot Machines Smoking Smoking-Cessation SNDRI Sobriety Social Assistance Social Media Social Security Soda Soda Addiction Sodium Sodium Ion Channel Space Monkey Speech Star Dust Striatum Subutex Successful Treatment Supreme Court of Canada Synapse Teenagers Tobacco Toll-Like receptor 4 (TLR4) Tooth Decay Tooth Enamel Tooth Erosion Treatment Trillium Drug Program Urine Sample Vaccine Vancouver Vanilla Sky Vaporize Vicodin Virus Vivitrol Welfare Wet Program White Lightning White Matter Wine Withdrawal